Electronic packaging for bio-diagnostic microfluidics application

Silicon based semiconductors techniques are creating a solid base for a new category of micro electro mechanical systems (MEMS) with reliable structures for microfluidic functions, handling either electrical signals or mechanical/physical parameters. A particular category of these early developed devices is constituted by Bio-MEMS, providing electro-microfluidic features in order to integrate in one system all the functional elements needed for a complete bio-assay response. New packaging architectures are then coming much more a reality and in particular some simple concept-structures for DNA analysis on a single silicon device are involved in this bio-tech environment. Some notes on core biological characterizations of PCR and Matrix-Spot detection structures are also present in this paper.