Title :
Definition of an agent-based model of the autoimmune response in Type 1 diabetes
Author :
Martínez, Ignacio V. ; Hernando, M. Elena ; Gómez, Enrique J. ; Villares, Ricardo ; Mellado, Mario
Author_Institution :
Dept. de Tecnol. Fotonica y Bioingenieria, Univ. Politec. de Madrid, Madrid, Spain
Abstract :
This work describes the architecture of an agent based computer model that simulates the autoimmune response in Type 1 diabetes in a three-dimensional cubic volume representing a fragment of pancreas of a mouse. Immune cells and β-cells are modeled as agents, making the abstraction of one cell - one agent. We present our preliminary results for the interactions between β-cell agents and macrophage agents and a model of cell motility in the continuous three-dimensional volume. This agent-based approach allows implementing multi-scale computational modeling capturing subcellular characteristics into cell agents and obtaining outcomes from agent populations at tissue and systemic levels.
Keywords :
diseases; medical computing; multi-agent systems; β-cell agents; agent based computer model; autoimmune response; cell motility model; immune cells; macrophage agents; mouse; multiscale computational modeling; pancreas fragment; subcellular characteristics; three-dimensional cubic volume; type 1 diabetes; Biological system modeling; Computational modeling; Diabetes; Immune system; Mathematical model; Object oriented modeling; Solid modeling; Agent-based model; Type 1 diabetes; autoimmunity; multi-scale modeling;
Conference_Titel :
Information Systems and Technologies (CISTI), 2012 7th Iberian Conference on
Conference_Location :
Madrid
Print_ISBN :
978-1-4673-2843-2
