Neuroplasticity and high frequency rTMS in hereditary pure cerebellar degeneration

Author

Nakamura, Yusaku ; Sakamoto, Hikaru ; Ueno, Satoshi ; Hirano, Makito

Author_Institution

Sch. of Med., Dept. of Neurology, Kinki Univ., Osaka-Sayama, Japan

fYear

2012

fDate

1-4 July 2012

Firstpage

142

Lastpage

146

Abstract

In patients with cerebellar ataxia, several abnormalities in cortical excitability by TMS had been observed. The aim of this study is to investigate the neurophysiological effect on the motor cortex after high frequency rTMS on motor cortex in patients with spinocerebellar degeneration (SCD). I waves facilitation and Intracortical inhibition in patients with cerebellar ataxia by a paired-pulse TMS was studied. And Cortical effect after 5Hz-rTMS on motor cortex was evaluated. I waves facilitation was significantly reduced in SCD, whereas for intracortical inhibition no significant change was found. 5Hz-rTMS on motor cortex can have some cortical facilitatory effect in SCD patients. Our study suggests high-frequency rTMS could have the neuromodulatory tool in patients with SCD.

Keywords

brain; high-frequency effects; neurophysiology; transcranial magnetic stimulation; cerebellar ataxia; cortical excitability; cortical facilitatory effect; frequency 5 Hz; hereditary pure cerebellar degeneration; high-frequency repetitive transcranial magnetic stimulation; intracortical inhibition; motor cortex; neuromodulatory tool; neurophysiological effect; neuroplasticity; spinocerebellar degeneration; Abstracts; Surface waves;

fLanguage

English

Publisher

ieee

Conference_Titel

Complex Medical Engineering (CME), 2012 ICME International Conference on

Conference_Location

Kobe

Print_ISBN

978-1-4673-1617-0

Type

conf

DOI

10.1109/ICCME.2012.6275679

Filename

6275679