Human encoded miRNAs that regulate the inflenenza virus genome

Motivation:MiRNAs can downregulate gene expression by mRNA cleavage or translational repression. Discovering human encoded miRNAs that regulate the influenza virus genome is important for molecular targets for drug development, and it also plays positive role in influenza control and prevention. Methods: We propose a new method based on scoring to discover human encoded miRNAs that regulate the influenza virus genome. The scoring based on the same complementary sites, the secondary structure of the complementary sites and the binding sites of all sequences respectively. Among them, taking the secondary structure as a vital factor is a new attempt. Results: Has-miR-489, has-miR-325, has-miR-876-3p and has-miR-2117 are targeted HA, PB2, MP and NS of influenza A, respectively.