Title :
Analysis of a HBV infection model with non-cytolytic cure process
Author_Institution :
Sch. of Sci., Beijing Univ. of Posts & Telecommun., Beijing, China
Abstract :
Mathematical models have been used to understand the factors that govern infectious disease progression in viral infections. Many models ignore the loss term of free virus particle when it enters the target cell. In this paper, we discuss a virus infection model with the loss term of free virus and the non-cytolytic loss of infected cells. Stable analysis of our model was given. If the basic reproduction number R0 <; 1, the infection-free equilibrium is globally asymptotically stable and the virus is cleared; if the basic reproduction number R0 >; 1, then the virus would persist in the host.
Keywords :
cellular biophysics; diseases; microorganisms; physiological models; HBV infection model analysis; free virus particle; globally asymptotically stable; infected cells; infectious disease progression; mathematical models; noncytolytic cure processing; noncytolytic loss; stable analysis; virus infection model; Analytical models; Asymptotic stability; Equations; Jacobian matrices; Mathematical model; Stability analysis; Steady-state; Mathematical model; stable analysis; virus dynamics;
Conference_Titel :
Systems Biology (ISB), 2012 IEEE 6th International Conference on
Conference_Location :
Xi´an
Print_ISBN :
978-1-4673-4396-1
Electronic_ISBN :
978-1-4673-4397-8
DOI :
10.1109/ISB.2012.6314127