Glucose-insulin model of glucose metabolism in acute diabetic swine based on Luenberger observer

Clinical studies have to be prepared meticulously to reduce the risk for each subject when testing new therapy devices. Here, the establisment of adequate animal trials could reduce the safety risks and accelerate the certification of technical developments for clinical studies. In particular, for the realisation of an artificial pancreas for type 1 diabetes patients, animal trials with Goettingen minipigs seem to be useful. To understand the glucose-insulin system in that breed and to design an adequate control algorithm for a future closed-loop therapy system, two different linear model approaches for the glucose metabolism are described. Therefore, two LUENBERGER observer were identified for a simple PT₂ and a more complex blood glucose trajectory approximation during oral glucose tolerance test and subcutaneously injected insulin dose. By analysing the observer feedback, it could be shown, that both approaches seem to be reasonable. Nevertheless, the models have to be improved in future by further glucose-insulin interactions and measurement data.