The topological features of nonessential-nonhub proteins in the protein-protein interaction network

Author

Yun-yuan, Dong ; Jun, Yang ; Qi-jun, Liu ; Zheng-hua, Wang

Author_Institution

Coll. of Comput., Nat. Univ. of Defense Technol., Changsha, China

Volume

1

fYear

2012

fDate

20-21 Oct. 2012

Firstpage

51

Lastpage

54

Abstract

One of the important problems in system biology is to discover the relationship between topological properties and functional features of proteins in protein-protein interaction (PPI) networks. There are many essential-nonhub proteins and lots of nonessential-nonhub proteins in the PPI network. Both essential-nonhub proteins and nonessential-nonhub proteins are low-connectivity proteins, but they have different lethality. In order to explain why nonessential-nonhub proteins are not essential, we compare them with essential-nonhub proteins from topological view. The comparison results show that there are statistical differences between nonessential-nonhub proteins and essential-nonhub proteins in centrality measures and clustering coefficient.

Keywords

molecular biophysics; proteins; statistical analysis; centrality measurement; clustering coefficient; essential-nonhub proteins; low-connectivity proteins; nonessential-nonhub proteins; protein-protein interaction network; statistical difference; system biology; topological features; topological properties; Bioinformatics; Educational institutions; Genomics; Integrated circuits; Nickel; Organisms; Proteins; centrality measure; clustering coefficient; essential-nonhub protein; nonessential-nonhub protein; protein-protein interaction network;

fLanguage

English

Publisher

ieee

Conference_Titel

System Science, Engineering Design and Manufacturing Informatization (ICSEM), 2012 3rd International Conference on

Conference_Location

Chengdu

Print_ISBN

978-1-4673-0914-1

Type

conf

DOI

10.1109/ICSSEM.2012.6340764

Filename

6340764