Continuous control of blood glucose in TIDM using fuzzy logic controller in insulin pump: A simulation study

This paper presents a closed-loop control system for regulating blood glucose level in type-1 diabetic patients. The goals of designing controller are 1. avoidance of hypoglycemia (blood glucose concentrations should be above 3mmol/l) and 2. reduction in the blood glucose level (average blood glucose should be less than 7mmol/l) in diabetic patients. An intensive therapy for these patients is described by a continuous subcutaneous insulin infusion pump which mimics the natural insulin secretion in healthy person. The control algorithm uses experience of physicians to treat this disease by using Mamdani-type fuzzy logic controller (FLC). Robustness of this controller is tested by a group of diabetic patients models. Then to assess the performance and capabilities of fuzzy controller, the results of FLC were compared to PID controller for each diabetic patient. The results showed that FLC has a more stable response in presence of uncertainty in system parameters which can vary from patient to patient.