Modeling the interplay between pathological angiogenesis and solid tumor growth: The anti-angiogenic treatment effect

Author

Argyri, Katerina D. ; Dionysiou, D.D. ; Stamatakos, Georgios S.

Author_Institution

Inst. of Commun. & Comput. Syst., Nat. Tech. Univ. of Athens, Zografos, Greece

fYear

2012

fDate

22-23 Oct. 2012

Firstpage

1

Lastpage

4

Abstract

In this paper, a previous continuum approach describing vascular tumor growth under angiogenic signaling [1] is developed and extended via the inclusion of bevacizumab pharmacokinetics. The modeling approach to the problem addressed includes inter alia the building of the model (selection of equations, related assumptions, coupling with a pharmacokinetic model tailored to the bevacizumab paradigm, implementation and numerical solution) as well as a study of the vascular tumor growth model with results for free growth and an intermittent bevacizumab mono-therapy schedule.

Keywords

blood vessels; drug delivery systems; drugs; numerical analysis; tumours; angiogenic signaling; antiangiogenic treatment effect; bevacizumab paradigm; bevacizumab pharmacokinetics; inter alia; intermittent bevacizumab monotherapy schedule; numerical solution; pathological angiogenesis; pharmacokinetic model; selection-of-equations; solid tumor growth; vascular tumor growth model; Biological system modeling; Cancer; Equations; Inhibitors; Mathematical model; Numerical models; Tumors;

fLanguage

English

Publisher

ieee

Conference_Titel

In Silico Oncology and Cancer Investigation - The TUMOR Project Workshop (IARWISOCI), 2012 5th International Advanced Research Workshop on

Conference_Location

Athens

Print_ISBN

978-1-4673-5024-2

Type

conf

Filename

6397181