From the Topological View to Explain Why False Hub is Not Essential

Centrality-lethality rule demonstrates that proteins with high degree in the protein-protein interaction (PPI) network are more likely to be essential than those selected by chance. Nevertheless, in PPI network, there are still many proteins with high degree are not essential (false hubs). Comparing the difference between false hubs and essential hubs from topological perspective, such as centrality measures, damage, clustering coefficient and interactions between neighbors, there are distinguishable significant properties of false hubs. False hubs have lower sub graph centrality and less interactions between neighbors, which could explain why they are not essential in some extent.