On the use of the bidomain model for computing the position and size of ischemic regions; a validation study

In this paper we discuss a framework involving exercise ECG testing and mathematical models for identifying is-chemic regions in the heart. More precisely, the ischemic regions are identified by minimizing the difference between recorded and simulated multi-channel ECG signals. Furthermore, we investigate how geometrical changes of the heart, lungs and torso affect the size and position of the ischemic regions that are calculated. To validate our findings, the computed ischemic regions are visualized in terms of images and compared with images taken with perfusion scintigraphy.