Title :
Plasmon-enhanced whispering gallery mode biosensing
Author_Institution :
Max Planck Inst. for the Sci. of Light, Erlangen, Germany
Abstract :
Whispering gallery mode (WGM) biosensors derive their unprecedented sensitivity for label-free detection of biomolecules from the high-quality (Q) factor of an optical resonance phenomenon. Plasmonic excitations in metal nanostructures which are able to localize the WGM field at the target binding site can further enhance sensitivity by local electric field amplification. Random nanoparticle layers and nanopost antennas are investigated for this purpose, and an efficiency parameter is introduced to quantitate the local field overlap with analyte molecules, a pre-requisite for single molecule detection.
Keywords :
Q-factor; amplification; biosensors; molecular biophysics; nanoparticles; nanophotonics; plasmonics; plasmons; proteins; Q-factor; analyte molecules; biomolecules; high-quality factor; label-free detection; local electric field amplification; metal nanostructures; nanopost antennas; optical resonance phenomenon; plasmon-enhanced whispering gallery mode biosensors; plasmonic excitation; protein; random nanoparticle layers; sensitivity effect; single molecule detection; Biosensors; DNA; Gold; ISO standards; Nanobioscience; Optical resonators;
Conference_Titel :
Photonics Global Conference (PGC), 2012
Conference_Location :
Singapore
Print_ISBN :
978-1-4673-2513-4
DOI :
10.1109/PGC.2012.6458007
