Title :
CMOS-based implantable glucose monitoring device with improved performance and reduced invasiveness
Author :
Kawamura, T. ; Masuda, K. ; Hirai, T. ; Ohta, Y. ; Motoyama, M. ; Takehara, H. ; Noda, T. ; Sasagawa, K. ; Tokuda, T. ; Okitsu, T. ; Takeuchi, S. ; Ohta, J.
Author_Institution :
Grad. Sch. of Mater. Sci., Nara Inst. of Sci. & Technol., Nara, Japan
Abstract :
An implantable glucose monitoring device based on a CMOS line sensor combined with a glucose-responsive fluorescent hydrogel is developed. An implantable glucose monitoring device with sufficient sensitivity and response time is realised, which is an improvement over the authors´ previous proof-of-concept device. A reduction of the sensor size made the device diameter injectable with a commercially available 16-gauge syringe needle. The sensor´s performance was confirmed through both in vitro and in vivo experiments.
Keywords :
CMOS image sensors; CMOS integrated circuits; biomedical equipment; blood; diseases; fluorescence; hydrogels; needles; patient monitoring; sugar; CMOS line sensor; CMOS-based implantable glucose monitoring device; commercially available 16-gauge syringe needle; glucose-responsive fluorescent hydrogel; implantable glucose monitoring device; injectable device diameter; proof-of-concept device; sensor performance;
Journal_Title :
Electronics Letters
DOI :
10.1049/el.2015.0612
