Droplet based lab-on-chip microfluidic Microsystems integrated nanostructured surfaces for high sensitive mass spectrometry analysis

Author

Perry, G. ; Lapierre, F. ; Coffinier, Y. ; Thomy, V. ; Boukherroub, R. ; CongXiang Lu ; Siu Hon Tsang ; Tay, B.K. ; Coquet, P.

Author_Institution

Inst. d´´Electron. de Microelectron. et de Nanotechnol. (IEMN, Univ. Lille 1, Villeneuve-d´´Ascq, France

fYear

2013

fDate

2-4 Jan. 2013

Firstpage

374

Lastpage

377

Abstract

We present in this paper a microsystem coupling electrowetting on digital microfluidic and nanostructured surfaces for matrix-free Laser Desorption/Ionization Mass Spectrometry (LDI-MS) analysis of small biomolecules. Silicon nanowires are processed to form highly sensitive pads for LDI analysis and also to produce superhydrophobic surfaces for enhanced transfer of droplets containing the analytes to the analyzing pads. By this way, analysis of low molecular weight compounds with high sensitivity can be achieved. In addition, wetting properties of carbon nanotubes surfaces are investigated in the perspective of further increasing the detection performances.

Keywords

desorption; drops; ionisation; lab-on-a-chip; mass spectroscopy; microfluidics; nanotechnology; nanowires; wetting; LDI-MS analysis; carbon nanotubes surfaces; droplet based lab-on-chip microfluidic microsystems integrated nanostructured surfaces; electrowetting; mass spectrometry analysis; matrix-free laser desorption-ionization mass spectrometry; silicon nanowires; superhydrophobic surfaces; Carbon nanotubes; Electrodes; Nanowires; Peptides; Silicon; Surface morphology; Surface treatment; Carbon Nanotubes; EWOD; Mass Spectrometry Analysis; Silicon Nanowires; Superhydrophobic Surfaces;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanoelectronics Conference (INEC), 2013 IEEE 5th International

Conference_Location

Singapore

ISSN

2159-3523

Print_ISBN

978-1-4673-4840-9

Electronic_ISBN

2159-3523

Type

conf

DOI

10.1109/INEC.2013.6466051

Filename

6466051