Title :
Pore dynamics induced by nsPEFs: A comparison between experimental and theoretical results
Author :
Lamberti, Patrizia ; Romeo, Stefania ; Sannino, Anna ; Scarfi, Maria Rosaria ; Tucci, Vincenzo ; Zeni, Olga
Author_Institution :
University of Salerno, Dept. of Electronic and Computer Engineering, Via Ponte Don Melillo - 84084 Fisciano (SA), Italy
Abstract :
Starting from experimental data where plasma membrane permeabilization has been demonstrated in human lymphoblastoid Jurkat T-cells exposed to a single 60ns, 2.5 MV/m pulsed electric field, a 2D numerical model has been exploited in order to describe the dynamics of pore formation and induced transmembrane voltage. The adopted approach, employed here for the first time for nanosecond duration pulses, represents an useful tool to give insight into the involved physical phenomena and drive the experimental design in addressing mechanistic understanding and applications.
Keywords :
Electroporation; FEM modeling; cell membrane; nsPEFs; pore density;
Conference_Titel :
Power Modulator and High Voltage Conference (IPMHVC), 2012 IEEE International
Conference_Location :
San Diego, CA, USA
Print_ISBN :
978-1-4673-1222-6
DOI :
10.1109/IPMHVC.2012.6518796
