In-vivo MR imaging of lipoprotein distribution and metabolism using spio-labeled lipoproteins at 3T

Author

Ittrich, H. ; Bruns, O. ; Bartelt, A. ; Peldschus, K. ; Kaul, Manohar ; Adam, Grain ; Heeren, J.

Author_Institution

IBMII, Univ. Med. Center Hamburg-Eppendorf, Hamburg, Germany

fYear

2013

fDate

23-24 March 2013

Firstpage

1

Lastpage

1

Abstract

TRL-NS is a potent MR contrast agent with comparable properties to TRL. Dynamic in-vivo MR measurements after application of TRL-NS showed a two phase SNR change with a rapid exponential SNR decrease in order of vena cava, aorta, portal vein followed by a protracted SNR recovery in all vessels. Liver and BAT showed an exponential SNR decline (rΔ0394;SNR_liver= -0.60 ±0.14 (p<;0.01); rΔSNR_BAT = -0.74±0.13 (p<;0.01)) indicating high metabolism, that was confirmed with radioactive measurements. Skeletal muscle (rΔSNR= -0.08±0.18), myocardium (rΔSNR= -0.10±0.15) and WAT (rΔSNR= -0.05±0.11) showed a non-significant decline trend in contrast to significant uptake measured by y-counting. Brain showed no significant SNR changes in correlation to radioisotope counting. Corresponding to MR imaging histology and electron microscopy confirmed a predominantly accumulation of TRL-NS in liver and brown adipose tissue.

Keywords

biomedical MRI; blood vessels; brain; cardiology; electron microscopy; liver; molecular biophysics; muscle; proteins; radioisotopes; MR contrast agent; MR imaging histology; SPIO-labeled lipoproteins; TRL-NS; aorta; brain; brown adipose tissue; dynamic in-vivo MR measurements; electron microscopy; in-vivo MR imaging; lipoprotein distribution; liver; magnetic flux density 3 T; metabolism; myocardium; portal vein; protracted SNR recovery; radioactive measurements; radioisotope counting; skeletal muscle; vena cava; vessels; y-counting; Biochemistry; Lipidomics; Magnetic resonance imaging; Mice; Real-time systems; Signal to noise ratio;

fLanguage

English

Publisher

ieee

Conference_Titel

Magnetic Particle Imaging (IWMPI), 2013 International Workshop on

Conference_Location

Berkeley, CA

Print_ISBN

978-1-4673-5520-9

Electronic_ISBN

978-1-4673-5521-6

Type

conf

DOI

10.1109/IWMPI.2013.6528361

Filename

6528361