Title :
The potential of clustered core magnetic particles for MPI
Author :
Gehrke, Nicole ; Heinke, D. ; Eberbeck, D. ; Briel, A.
Author_Institution :
nanoPET Pharma GmbH, Berlin, Germany
Abstract :
No obvious differences between the structures of the different particles were found, yet their MPI efficacy varies significantly: the MPS amplitude differs by a factor of up to 6 in the lower and 11 in the higher harmonics between the highest (#1) and lowest (#2) MPI efficacy particles synthesized here. In comparison to Resovist and FeraSpin R this means an improvement by a factor of about three in the lower and two in the higher harmonics in case of the high efficacy particles (#1). Our results from static magnetization measurements allow to quantitatively understand this increase. Such an increase does not represent the theoretical limit, but so far similar performance was only found for size optimized particles obtained from the best state-of-the-art clustered core MPI tracer Resovist and FeraSpin R from aqueous synthesis [2,3] as well as certain mono-crystalline core particles from organic synthesis [4].
Keywords :
biomagnetism; biomedical MRI; magnetic particles; magnetisation; particle size; aqueous synthesis; clustered core magnetic particles; diagnostic imaging technology; harmonics; magnetic particle imaging; magnetic particle spectra amplitude; monocrystalline core particles; optimized particle size; organic synthesis; state-of-the-art clustered core MPI tracer FeraSpin R; state-of-the-art clustered core MPI tracer Resovist; static magnetization measurements; Imaging; Iron; Magnetic cores; Magnetic particles; Magnetization; Nanoparticles; Standards;
Conference_Titel :
Magnetic Particle Imaging (IWMPI), 2013 International Workshop on
Conference_Location :
Berkeley, CA
Print_ISBN :
978-1-4673-5520-9
Electronic_ISBN :
978-1-4673-5521-6
DOI :
10.1109/IWMPI.2013.6528368
