Simple way to obtain pH-sensitive drug release from functional mesoporous silica materials

Author

Di Xiang ; Huiming Lin ; Wei Guo ; Jie Ma ; Liru Cui ; Jingjie Jiang ; Fengyu Qu

Author_Institution

Key Lab. of Design & Synthesis of Functional Mater. & Green Catalysis, Harbin Normal Univ., Harbin, China

Volume

8

Issue

4

fYear

2014

fDate

12 2014

Firstpage

179

Lastpage

183

Abstract

A novel pH-sensitive drug release system has been synthesised by functional mesoporous silica materials. SBA-15, calcium modified SBA-15 (Ca-SBA-15) and phosphate modified SBA-15 (PO₄-SBA-15) were synthesised using solvent evaporation method. It is a simple and feasible way to prepare the doping mesoporous silica materials. They show the large surface are, high pore volume and uniform pore size. Metformin hydrochloride was used as the model drug, and the control release behaviour was investigated. The functional mesoporous silica materials show the pH sensitive drug release behaviour because of the adjustable interaction between the drug molecule and the host.

Keywords

biochemistry; biomedical materials; calcium; doping; drug delivery systems; drugs; evaporation; mesoporous materials; molecular biophysics; pH; phosphorus compounds; silicon compounds; Ca-SiO₂; PO₄-SiO₂; calcium modifled SBA-15; doping mesoporous silica materials; drug molecule; functional mesoporous silica materials; metformin hydrochloride; pH-sensitive drug release; phosphate modifled SBA-15; solvent evaporation method;

fLanguage

English

Journal_Title

Nanobiotechnology, IET

Publisher

iet

ISSN

1751-8741

Type

jour

DOI

10.1049/iet-nbt.2013.0019

Filename

6968717