MitomiRs and Energetic Regulation

Author

Demongeot, Jacques ; Cohen, Oren ; Doncescu, Andrei ; Henrion-Caude, A.

Author_Institution

Fac. of Med., Univ. J. Fourier Grenoble, La Tronche, France

fYear

2013

fDate

25-28 March 2013

Firstpage

1501

Lastpage

1508

Abstract

MicroRNAs are parts of nuclear and mitochondrial genomes which pertain to the not coding genome. They have a partly unspecific role of inhibition, preventing the weakest part of the genetic regulatory networks to be expressed and preventing the appearance of a too large number of attractors in these networks, i.e., forcing the network to have only one or two possible dynamic behaviours for fulfilling a precise function. They have also a great influence on the chromatin clock, which ensures the real mode of updating of genetic regulatory networks. We analyze this influence as well as their impact on important functions like p53 network control.

Keywords

cellular biophysics; genetics; genomics; proteins; MicroRNA; MitomiR; attractor prevention; chromatin clock; dynamic behaviours; energetic regulation; genetic regulatory networks; inhibition; mitochondrial genomes; p53 network control; Clocks; Encoding; Genomics; Polymers; Proteins; RNA; Chromatin clock control; Energetic regulation; Genetic networks; MicroRNAs;

fLanguage

English

Publisher

ieee

Conference_Titel

Advanced Information Networking and Applications Workshops (WAINA), 2013 27th International Conference on

Conference_Location

Barcelona

Print_ISBN

978-1-4673-6239-9

Electronic_ISBN

978-0-7695-4952-1

Type

conf

DOI

10.1109/WAINA.2013.89

Filename

6550609