DocumentCode
61502
Title
A Simple Fixed Parameter Tractable Algorithm for Computing the Hybridization Number of Two (Not Necessarily Binary) Trees
Author
Piovesan, Teresa ; Kelk, Steven M.
Author_Institution
Dept. of Knowledge Eng. (DKE), Maastricht Univ., Maastricht, Netherlands
Volume
10
Issue
1
fYear
2013
fDate
Jan.-Feb. 2013
Firstpage
18
Lastpage
25
Abstract
Here, we present a new fixed parameter tractable algorithm to compute the hybridization number r of two rooted, not necessarily binary phylogenetic trees on taxon set X in time (6rr!) · poly(n), where n = |X|. The novelty of this approach is its use of terminals, which are maximal elements of a natural partial order on X, and several insights from the softwired clusters literature. This yields a surprisingly simple and practical bounded-search algorithm and offers an alternative perspective on the underlying combinatorial structure of the hybridization number problem.
Keywords
biology computing; evolution (biological); genetics; trees (mathematics); binary phylogenetic trees; bounded-search algorithm; combinatorial structure; fixed parameter tractability; hybridization number; parameter tractable algorithm; taxon set X; Bioinformatics; Clustering algorithms; Computational biology; Phylogeny; Polynomials; Silicon; Vegetation; Phylogenetic network; fixed parameter tractability; nonbinary; Algorithms; Cluster Analysis; Computational Biology; Hybridization, Genetic; Phylogeny;
fLanguage
English
Journal_Title
Computational Biology and Bioinformatics, IEEE/ACM Transactions on
Publisher
ieee
ISSN
1545-5963
Type
jour
DOI
10.1109/TCBB.2012.134
Filename
6338921
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