• DocumentCode
    61502
  • Title

    A Simple Fixed Parameter Tractable Algorithm for Computing the Hybridization Number of Two (Not Necessarily Binary) Trees

  • Author

    Piovesan, Teresa ; Kelk, Steven M.

  • Author_Institution
    Dept. of Knowledge Eng. (DKE), Maastricht Univ., Maastricht, Netherlands
  • Volume
    10
  • Issue
    1
  • fYear
    2013
  • fDate
    Jan.-Feb. 2013
  • Firstpage
    18
  • Lastpage
    25
  • Abstract
    Here, we present a new fixed parameter tractable algorithm to compute the hybridization number r of two rooted, not necessarily binary phylogenetic trees on taxon set X in time (6rr!) · poly(n), where n = |X|. The novelty of this approach is its use of terminals, which are maximal elements of a natural partial order on X, and several insights from the softwired clusters literature. This yields a surprisingly simple and practical bounded-search algorithm and offers an alternative perspective on the underlying combinatorial structure of the hybridization number problem.
  • Keywords
    biology computing; evolution (biological); genetics; trees (mathematics); binary phylogenetic trees; bounded-search algorithm; combinatorial structure; fixed parameter tractability; hybridization number; parameter tractable algorithm; taxon set X; Bioinformatics; Clustering algorithms; Computational biology; Phylogeny; Polynomials; Silicon; Vegetation; Phylogenetic network; fixed parameter tractability; nonbinary; Algorithms; Cluster Analysis; Computational Biology; Hybridization, Genetic; Phylogeny;
  • fLanguage
    English
  • Journal_Title
    Computational Biology and Bioinformatics, IEEE/ACM Transactions on
  • Publisher
    ieee
  • ISSN
    1545-5963
  • Type

    jour

  • DOI
    10.1109/TCBB.2012.134
  • Filename
    6338921