In vivo microwave dielectric spectroscopy of breast tumor xenografts with intra-tumoral injections of SWCNT dispersions

Author

Fuqiang Gao ; Hagness, Susan C. ; Booske, John H. ; Xie, Shawn X. ; Sitharaman, Balaji

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Wisconsin-Madison, Madison, WI, USA

fYear

2013

fDate

6-9 May 2013

Firstpage

1441

Lastpage

1444

Abstract

We present a preliminary in vivo study of the microwave-frequency dielectric properties of mice breast tumor xenografts with accumulation of single-walled carbon nanotubes (SWCNTs). Dispersions of SWCNT-DSPE-PEG at various concentrations were injected directly into 22 tumors. Dielectric properties (1-6 GHz) before and after the injection were characterized using an open-ended coaxial probe technique. Baseline measurements (sham control and PEG only) were also conducted in 12 tumors. We found at least a ~10% relative permittivity enhancement effect upon injection of 100 μl of SWCNT stock solutions at concentrations ranging between 3 and 7 mg/ml.

Keywords

bioelectric phenomena; biomedical materials; biomedical measurement; carbon nanotubes; disperse systems; microwave spectra; nanomedicine; nanoparticles; permittivity; polymers; tumours; C; SWCNT stock solution; SWCNT-DSPE-PEG dispersion; coaxial probe technique; frequency 1 GHz to 6 GHz; in vivo microwave dielectric spectroscopy; intratumoral injection; mice breast tumor xenograf; microwave frequency dielectric property; relative permittivity enhancement effect; single-walled carbon nanotube; Dielectric measurement; Dielectrics; In vivo; Needles; Permittivity; Probes; Tumors; breast tumors; carbon nanotubes; in vivo tissue characterization; microwave-frequency dielectric properties;

fLanguage

English

Publisher

ieee

Conference_Titel

Instrumentation and Measurement Technology Conference (I2MTC), 2013 IEEE International

Conference_Location

Minneapolis, MN

ISSN

1091-5281

Print_ISBN

978-1-4673-4621-4

Type

conf

DOI

10.1109/I2MTC.2013.6555652

Filename

6555652