Mono-, di-, tri-nucleotide tandem repeats and mutation profile of peptidoglycan stimulated NOD2-encoding Card15

Author

Sim-Hui Tee ; Quek, Albert

Author_Institution

Multimedia Univ., Cyberjaya, Malaysia

fYear

2013

fDate

7-9 April 2013

Firstpage

878

Lastpage

882

Abstract

Immune system is a subtle physiological mechanism that implicates various genes. NOD2-encoding Card15 , which has a role in pathogen sensing, was investigated in this research to understand its extensiveness of tandem repeats and mutation distribution. Using a bioinformatics approach, mono-, di-, and trinucleotide tandem repeats were analyzed and mutation data were mined. The results of this study provide insights for the development of pharmaceutical strategies against the pathogenesis of Card15-implicated immune diseases.

Keywords

bioinformatics; diseases; genetics; pharmaceuticals; bioinformatics approach; dinucleotide tandem repeat; immune system; mononucleotide tandem repeat; mutation profile; pathogen sensing; peptidoglycan stimulated NOD2encoding Card15 gene; pharmaceutical strategy; physiological mechanism; trinucleotide tandem repeat; Bioinformatics; Biological system modeling; Computational modeling; Diseases; Genomics; Immune system; Sensors; bioinformatics; data mining; gene; mutation; scientific computing; tandem repeats;

fLanguage

English

Publisher

ieee

Conference_Titel

Business Engineering and Industrial Applications Colloquium (BEIAC), 2013 IEEE

Conference_Location

Langkawi

Print_ISBN

978-1-4673-5967-2

Type

conf

DOI

10.1109/BEIAC.2013.6560262

Filename

6560262