Title :
Mono-, di-, tri-nucleotide tandem repeats and mutation profile of peptidoglycan stimulated NOD2-encoding Card15
Author :
Sim-Hui Tee ; Quek, Albert
Author_Institution :
Multimedia Univ., Cyberjaya, Malaysia
Abstract :
Immune system is a subtle physiological mechanism that implicates various genes. NOD2-encoding Card15 , which has a role in pathogen sensing, was investigated in this research to understand its extensiveness of tandem repeats and mutation distribution. Using a bioinformatics approach, mono-, di-, and trinucleotide tandem repeats were analyzed and mutation data were mined. The results of this study provide insights for the development of pharmaceutical strategies against the pathogenesis of Card15-implicated immune diseases.
Keywords :
bioinformatics; diseases; genetics; pharmaceuticals; bioinformatics approach; dinucleotide tandem repeat; immune system; mononucleotide tandem repeat; mutation profile; pathogen sensing; peptidoglycan stimulated NOD2encoding Card15 gene; pharmaceutical strategy; physiological mechanism; trinucleotide tandem repeat; Bioinformatics; Biological system modeling; Computational modeling; Diseases; Genomics; Immune system; Sensors; bioinformatics; data mining; gene; mutation; scientific computing; tandem repeats;
Conference_Titel :
Business Engineering and Industrial Applications Colloquium (BEIAC), 2013 IEEE
Conference_Location :
Langkawi
Print_ISBN :
978-1-4673-5967-2
DOI :
10.1109/BEIAC.2013.6560262
