Title :
Numerical simulation of the hydrodynamics of endothelial glycocalyx under shear flow
Author :
Shangjun Ye ; Wen Wang ; Xueming Shao
Author_Institution :
Inst. of Fluid Eng., Zhejiang Univ., Hangzhou, China
Abstract :
Endothelial glycocalyx has been recognized as a mechanotransducer of shear stress to the intracellular cytoskeleton. The elastic property of glycocalyx plays an important role in the red cell movement in the capillary vessels, but the measurement of rigidity is a great challenge. In this paper, we hypothesize that the support force of glycocalyx is caused by the interaction of electrostatic force of the protein in the glycocalyx. This effort is studied by introducing a beads-stick model with negatively charged core protein in each glycocalyx strand linked by a rigid stick. The deformation and recovery caused by the shear stress has been investigated.
Keywords :
biological fluid dynamics; cell motility; elasticity; hydrodynamics; molecular biophysics; numerical analysis; proteins; shear deformation; shear flow; shear modulus; beads-stick model; capillary vessels; deformation; elastic property; electrostatic force interaction; endothelial glycocalyx; glycocalyx strand; hydrodynamics; intracellular cytoskeleton; mechanotransducer; negatively charged core protein; numerical simulation; red cell movement; rigidity measurement; shear flow; shear stress; Drag; Equations; Force; Mathematical model; Permeability; Proteins;
Conference_Titel :
Control and Automation (ICCA), 2013 10th IEEE International Conference on
Conference_Location :
Hangzhou
Print_ISBN :
978-1-4673-4707-5
DOI :
10.1109/ICCA.2013.6565182
