Modeling and simulation of ventricular repolarization or T-wave of ECG of subjects with type 1 diabetes during adrenaline infusions

Increased catecholamine activity, both endogenous, and through medications, it has long been recognized to increase the risk of cardiac death. This paper proposes the use of the Bueno-Orovio - Cherry - Fenton model to understand the behavior of ventricular cells: Endocardium, Myocardium and Epicardial, through the transmural ECG generated by the weighted sum of action potentials of the three ventricular cells. These results were validated with a dataset of Vectorcardiograms according to Frank VCG-lead system (X, Y, Z) of 22 subjects with type 1 diabetes along adrenaline infusion, aged 20 to 40 years. Moreover, it was analyzed all 12-lead ECG, calculated from VCG´s by using the transform Dower. Finally, due to the sensitivity of the potassium current in the myocardium cells and the simulated transmural ECG, decrements considerably bigger than those used in this study could generate early afterdepolarization (EAD), flattening and inversion of the T-wave.