Title :
On the response of nanoelectrode capacitive biosensors to DNA and PNA strands
Author :
Pittino, Federico ; Passerini, Federico ; Palestri, Pierpaolo ; Selmi, Luca ; Widdershoven, Frans
Author_Institution :
DIEGM, Univ. degli Studi di Udine, Udine, Italy
Abstract :
This paper investigates the response of a nanoelectrode based capacitive biosensor to the presence of single and double strands of DNA/PNA. The expected admittance spectrum for an idealized system with cylindrical symmetry, where the biomolecule is represented by a simple dielectric and charged rod, is calculated over a broad frequency range extending from below to above the electrolyte´s dielectric relaxation cut-off frequency. DNA and PNA hybridization is also considered. The results provide indications on optimum detection conditions for admittance based DNA biosensors.
Keywords :
DNA; biosensors; capacitive sensors; electrochemical electrodes; electrolytes; molecular biophysics; nanosensors; DNA hybridization; DNA strand; PNA hybridization; PNA strand; admittance spectrum; biomolecule; broad frequency range; charged rod; cylindrical symmetry; electrolyte dielectric relaxation cut-off frequency; nanoelectrode based capacitive biosensor; nanoelectrode capacitive biosensors; optimum conditions; simple dielectric; Admittance; Biological system modeling; Biosensors; Capacitance; DNA; Electrodes; Mathematical model;
Conference_Titel :
Advances in Sensors and Interfaces (IWASI), 2013 5th IEEE International Workshop on
Conference_Location :
Bari
Print_ISBN :
978-1-4799-0039-8
DOI :
10.1109/IWASI.2013.6576088
