• DocumentCode
    636246
  • Title

    Dictionary learning improves subtyping of breast cancer aCGH data

  • Author

    Masecchia, Salvatore ; Barla, Annalisa ; Salzo, Saverio ; Verri, Alessandro

  • Author_Institution
    DIBRIS, Univ. of Genova, Genoa, Italy
  • fYear
    2013
  • fDate
    3-7 July 2013
  • Firstpage
    604
  • Lastpage
    607
  • Abstract
    The advent of Comparative Genomic Hybridization (CGH) data led to the development of new mathematical models and computational methods to automatically infer chromosomal alterations. In this work we tackle a standard clustering problem exploiting the good representation properties of a novel method based on dictionary learning. The identified dictionary atoms, which show co-occuring shared alterations among samples, can be easily interpreted by domain experts. We compare a state-of-the-art approach with an original method on a breast cancer dataset.
  • Keywords
    biological organs; cancer; genomics; mathematical analysis; physiological models; CGH data; breast cancer dataaset; chromosomal alterations; comparative genomic hybridization data; computational methods; dictionary atoms; dictionary learning; mathematical models; standard clustering problem; state-of-the-art approach; Bioinformatics; Biological cells; Breast cancer; Dictionaries; Genomics; Tumors;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
  • Conference_Location
    Osaka
  • ISSN
    1557-170X
  • Type

    conf

  • DOI
    10.1109/EMBC.2013.6609572
  • Filename
    6609572