DocumentCode
636246
Title
Dictionary learning improves subtyping of breast cancer aCGH data
Author
Masecchia, Salvatore ; Barla, Annalisa ; Salzo, Saverio ; Verri, Alessandro
Author_Institution
DIBRIS, Univ. of Genova, Genoa, Italy
fYear
2013
fDate
3-7 July 2013
Firstpage
604
Lastpage
607
Abstract
The advent of Comparative Genomic Hybridization (CGH) data led to the development of new mathematical models and computational methods to automatically infer chromosomal alterations. In this work we tackle a standard clustering problem exploiting the good representation properties of a novel method based on dictionary learning. The identified dictionary atoms, which show co-occuring shared alterations among samples, can be easily interpreted by domain experts. We compare a state-of-the-art approach with an original method on a breast cancer dataset.
Keywords
biological organs; cancer; genomics; mathematical analysis; physiological models; CGH data; breast cancer dataaset; chromosomal alterations; comparative genomic hybridization data; computational methods; dictionary atoms; dictionary learning; mathematical models; standard clustering problem; state-of-the-art approach; Bioinformatics; Biological cells; Breast cancer; Dictionaries; Genomics; Tumors;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location
Osaka
ISSN
1557-170X
Type
conf
DOI
10.1109/EMBC.2013.6609572
Filename
6609572
Link To Document