DocumentCode :
636449
Title :
Estimation of cardiac output and total peripheral resistance in preterm infants by arterial waveform analysis
Author :
Ying Zhang ; Chan, Gregory S. H. ; Tracy, Mark B. ; Hinder, Murray ; Redmond, Stephen J. ; Savkin, Andrey V. ; Lovell, Nigel H.
Author_Institution :
Sch. of Electr. Eng. & Telecommun., Univ. of New South Wales, Sydney, NSW, Australia
fYear :
2013
fDate :
3-7 July 2013
Firstpage :
2308
Lastpage :
2311
Abstract :
This study investigated whether arterial blood pressure waveform analysis could be useful for estimating left ventricular outflow (LVO) and total peripheral resistance (TPR) in preterm infants. A cohort of 27 infants were studied, with 89 measurements of left ventricular outflow (LVO) using Doppler echocardiography and arterial pressure using catheters, performed in 0, 12, 24 and 36 hours after birth. TPR was computed as mean arterial pressure divided by LVO. The diastolic decay rate (1/τ) was obtained via fitting an exponential function to the last one third of each arterial pulse, with the mean rate computed from 50 pulses selected from each infant. This decay rate was considered to be inversely related to TPR while positively related to LVO. The results of regression analysis have confirmed that the diastolic decay rate had significant positive and negative relationships with LVO and TPR respectively(r = 0.383, P = 0.0002 and r = -0.379, P = 0.0002 respectively). These preliminary results demonstrated the potential utility of arterial pressure waveform analysis for estimating LVO and TPR in preterm infants, but more advanced multi-parameter models may be needed to improve accuracy of the estimation.
Keywords :
blood pressure measurement; blood vessels; cardiology; catheters; echocardiography; paediatrics; regression analysis; waveform analysis; Doppler echocardiography; LVO; TPR; arterial blood pressure waveform analysis; cardiac output; catheters; diastolic decay rate; left ventricular outflow measurements; multiparameter models; preterm infants; regression analysis; time 0 hour to 36 hour; total peripheral resistance; Australia; Blood pressure; Estimation; Heart rate; Pediatrics; Signal analysis; Ultrasonic variables measurement;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
ISSN :
1557-170X
Type :
conf
DOI :
10.1109/EMBC.2013.6609999
Filename :
6609999
Link To Document :
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