EEG source localization in full-term newborns with hypoxic-ischemia

Author

Jennekens, W. ; Dankers, Frank ; Blijham, Paul ; Cluitmans, Pierre ; van Pul, C. ; Andriessen, Peter

Author_Institution

Dept. of Med. Phys. & Technol., Maasstad Hosp., Rotterdam, Netherlands

fYear

2013

fDate

3-7 July 2013

Firstpage

3291

Lastpage

3294

Abstract

The aim of this study was to evaluate EEG source localization by standardized weighted low-resolution brain electromagnetic tomography (swLORETA) for monitoring of full-term newborns with hypoxic-ischemic encephalopathy, using a standard anatomic head model. Three representative examples of neonatal hypoxic-ischemia were included. The method was validated with MRI data. Hypoxic-ischemic areas, visible on MRI, correlated well with swLORETA current density distributions. In addition, neonatal seizure activity may be localized. The calculated current density distributions provide easy-to-interpret localized information about neonatal brain function, which may enable detailed longitudinal monitoring and potential assessment of treatment efficacy.

Keywords

biomedical MRI; current density; diseases; electroencephalography; paediatrics; patient monitoring; physiological models; tomography; EEG source localization; MRI data; current density distribution calculation; full-term newborn monitoring; hypoxic ischemic area; hypoxic ischemic encephalopathy; longitudinal monitoring; neonatal brain function; neonatal hypoxic ischemia; neonatal seizure activity localization; standard anatomic head model; standardized weighted low resolution brain electromagnetic tomography; swLORETA; treatment efficacy assessment; Brain modeling; Current density; Electroencephalography; Head; Image segmentation; Magnetic resonance imaging; Pediatrics;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE

Conference_Location

Osaka

ISSN

1557-170X

Type

conf

DOI

10.1109/EMBC.2013.6610244

Filename

6610244