Title :
EEG source localization in full-term newborns with hypoxic-ischemia
Author :
Jennekens, W. ; Dankers, Frank ; Blijham, Paul ; Cluitmans, Pierre ; van Pul, C. ; Andriessen, Peter
Author_Institution :
Dept. of Med. Phys. & Technol., Maasstad Hosp., Rotterdam, Netherlands
Abstract :
The aim of this study was to evaluate EEG source localization by standardized weighted low-resolution brain electromagnetic tomography (swLORETA) for monitoring of full-term newborns with hypoxic-ischemic encephalopathy, using a standard anatomic head model. Three representative examples of neonatal hypoxic-ischemia were included. The method was validated with MRI data. Hypoxic-ischemic areas, visible on MRI, correlated well with swLORETA current density distributions. In addition, neonatal seizure activity may be localized. The calculated current density distributions provide easy-to-interpret localized information about neonatal brain function, which may enable detailed longitudinal monitoring and potential assessment of treatment efficacy.
Keywords :
biomedical MRI; current density; diseases; electroencephalography; paediatrics; patient monitoring; physiological models; tomography; EEG source localization; MRI data; current density distribution calculation; full-term newborn monitoring; hypoxic ischemic area; hypoxic ischemic encephalopathy; longitudinal monitoring; neonatal brain function; neonatal hypoxic ischemia; neonatal seizure activity localization; standard anatomic head model; standardized weighted low resolution brain electromagnetic tomography; swLORETA; treatment efficacy assessment; Brain modeling; Current density; Electroencephalography; Head; Image segmentation; Magnetic resonance imaging; Pediatrics;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
DOI :
10.1109/EMBC.2013.6610244
