DocumentCode
636670
Title
A tumor-immune mathematical model of CD4+ T helper cell dependent tumor regression by oncogene inactivation
Author
Nwabugwu, Chinyere I. ; Rakhra, Kavya ; Felsher, Dean W. ; Paik, David S.
Author_Institution
Electr. Eng. Dept., Stanford Univ., Stanford, CA, USA
fYear
2013
fDate
3-7 July 2013
Firstpage
4529
Lastpage
4532
Abstract
Understanding the complex dynamics between the tumor cells and the host immune system will be key to improved therapeutic strategies against cancer. We propose an ODE-based mathematical model of both the tumor and immune system and how they respond to inactivation of the driving oncogene. Our model supports experimental results showing that cellular senescence of tumor cells is dependent on CD4+ T helper cells, leading to relapse of tumors in immunocompromised hosts.
Keywords
cancer; cellular biophysics; genetics; tumours; CD4+ T helper cell; ODE-based mathematical model; cancer; cellular senescence; host immune system; oncogene inactivation; therapeutic strategies; tumor regression; tumor relapse; tumor-immune mathematical model; Cancer; Immune system; Mathematical model; Mice; Sociology; Statistics; Tumors;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location
Osaka
ISSN
1557-170X
Type
conf
DOI
10.1109/EMBC.2013.6610554
Filename
6610554
Link To Document