Title :
A tumor-immune mathematical model of CD4+ T helper cell dependent tumor regression by oncogene inactivation
Author :
Nwabugwu, Chinyere I. ; Rakhra, Kavya ; Felsher, Dean W. ; Paik, David S.
Author_Institution :
Electr. Eng. Dept., Stanford Univ., Stanford, CA, USA
Abstract :
Understanding the complex dynamics between the tumor cells and the host immune system will be key to improved therapeutic strategies against cancer. We propose an ODE-based mathematical model of both the tumor and immune system and how they respond to inactivation of the driving oncogene. Our model supports experimental results showing that cellular senescence of tumor cells is dependent on CD4+ T helper cells, leading to relapse of tumors in immunocompromised hosts.
Keywords :
cancer; cellular biophysics; genetics; tumours; CD4+ T helper cell; ODE-based mathematical model; cancer; cellular senescence; host immune system; oncogene inactivation; therapeutic strategies; tumor regression; tumor relapse; tumor-immune mathematical model; Cancer; Immune system; Mathematical model; Mice; Sociology; Statistics; Tumors;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE
Conference_Location :
Osaka
DOI :
10.1109/EMBC.2013.6610554
