Entropy analysis of MEG background activity in Attention-Deficit/Hyperactivity Disorder

Author

Gomez, Christopher ; Poza, Jesus ; Fernandez, Alicia ; Bachiller, Alejandro ; Gomez, Jose ; Hornero, Roberto

Author_Institution

Dept. of Signal Theor. & Commun., Univ. of Valladolid, Valladolid, Spain

fYear

2013

fDate

3-7 July 2013

Firstpage

5057

Lastpage

5060

Abstract

The aim of this study was to analyze the magnetoencephalography (MEG) background activity in Attention-Deficit/Hyperactivity Disorder (ADHD) using fuzzy entropy (FuzzyEn), an entropy measure that quantifies signal irregularity. Five minutes of recording were acquired with a 148-channel whole-head magnetometer in 14 ADHD patients and 14 control children. Our results showed that MEG activity was more regular in ADHD patients than in controls. Additionally, there were statistically significant differences (p <; 0.01, Student´s t-test with Bonferroni´s correction) in the five analyzed brain regions: anterior, central, posterior, left lateral, and right lateral. Using receiver operating characteristic (ROC) curves, the highest values of accuracy (82.14%) and area under the ROC curve (0.9005) were achieved in anterior area. Our results support the hypothesis that ADHD is characterized by a delay of cortical maturation in the prefrontal cortex.

Keywords

entropy; fuzzy set theory; magnetoencephalography; medical disorders; medical signal processing; paediatrics; sensitivity analysis; 148-channel whole-head magnetometer; ADHD patients; Attention-Deficit/Hyperactivity Disorder; Bonferroni´s correction; FuzzyEn; MEG activity; MEG background activity; anterior brain region; central brain region; children; cortical maturation delay; entropy analysis; fuzzy entropy; left lateral brain region; magnetoencephalography background activity; posterior brain region; prefrontal cortex; receiver operating characteristic curves; right lateral brain region; signal irregularity; student´s t-test; Accuracy; Brain; Complexity theory; Electroencephalography; Entropy; Pediatrics; Time series analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE

Conference_Location

Osaka

ISSN

1557-170X

Type

conf

DOI

10.1109/EMBC.2013.6610685

Filename

6610685