Toward implantable glucometer: Design, modeling and experimental results

We put forward an implantable glucometers using a biologically inspired sensor (BioS) method. In this method, engineered glucokinase (GLK) molecules are used as nanoscale glucometers. Herein, we describe two computational and experimental models of GLKs exposed to glucose molecules. The simulation results significantly show the detection of GLK binding to glucose. We thereafter reveal the applicability of this technique for continuous glucose monitoring by demonstrating and discussing the experimental results. Based on these results the glucose measurement with various glucose concentrations (0.5 mM, 1 mM and 2.5 mM) were precisely performed and repeated for more than 4 weeks. These results prove the advantage of proposed BioS method for continuous measurement of glucose.