Microfluidic system using microneedles for targeted drug delivery in cancer therapy

Author

Rajeswari, N. Raja ; Malliga, P.

Author_Institution

Dept. of ECE, DMI Coll. of Eng., Chennai, India

fYear

2013

fDate

28-29 March 2013

Firstpage

53

Lastpage

59

Abstract

In chemotherapy treatment of cancers, drug delivery has a significant impact on the therapeutic value of medication. Transdermal drug delivery uses microneedles to penetrate easily into the tumor by creating holes in the epidermis & providing a painless drug delivery. Microneedles are safer alternative to hypodermic needle injections in delivery of drugs. They could also be used for targeting of the bioactive for treating cancers. This paper focuses that microneedles represent a promising microfabricated device that can be used for drug delivery system in cancer therapy. A drug reservoir with microneedles is designed and analyzed by using COMSOL software. From simulation results, an optimal design is recommended for microfluidics based drug delivery system in cancer therapy.

Keywords

cancer; drug delivery systems; microfluidics; needles; patient treatment; COMSOL software; bioactive; cancer therapy; cancer treatment; chemotherapy treatment; drug delivery system; drug reservoir; hypodermic needle injections; medication; microfabricated device; microfluidics based drug delivery system; microneedles; optimal design; painless drug delivery; targeted drug delivery; therapeutic value; transdermal drug delivery; Bismuth; Drugs; Etching; Manganese; Polymers; Tumors; COMSOL; Drugdelivery; Microfluidics; Microneedles; cancer therapy;

fLanguage

English

Publisher

ieee

Conference_Titel

Smart Structures and Systems (ICSSS), 2013 IEEE International Conference on

Conference_Location

Chennai

Print_ISBN

978-1-4673-6240-5

Type

conf

DOI

10.1109/ICSSS.2013.6623000

Filename

6623000