Natural economic binding agent exploration for effectual Pharmaceutical Formulation using CANAL technique of data mining

Oral tablets have remained the most common dosage form by which drugs are usually administered to patients because of their advantages over the other dosage forms. The rate of release of drug from the tablet to know the drug availability is based on the process of disintegration and dissolution. In order to formulate orally fast disintegrating tablet (FDT), the usage of appropriate binder is also important which can drastically increase the rate of dissolution of oral dosage. In this study, Binders from different origins were used via wet granulation at concentrations ranging from 1.0 - 5.0% w/w to make paracetamol tablets, The mechanical and release properties of paracetamol tablets formulated with Cashew gum (CAG), Povidone (PVP), Gelatin (GEL), Okra gum (OKG) and Hydroxypropylmethyl cellulose (HMPC) as binders were studied and compared. The CANAL technique of data mining is proposed to show that the BFI values of tablets formulated with OKG were the lowest at all binder concentrations and which can increase the rate of dissolution with moderate the disintegration time. For the CANAL technique, sample calculated data of the measured tensile strength (TS), brittle fracture index (BFI), friability (F), disintegration time (DT) and percentage of drug released (PDR) of different binder agent formulation were used. The drug release of the Paracetamol tablet from a particular formulation is taken on 15th min and compared with the other formulation. Finally the significant method of formulation with appropriate binder with the average concentration is identified and thus the fast dissolution rate of soluble drug was attained using CANAL technique of data mining. Microsoft Business Intelligence Analysis Service 2008 software is used to ensure the CANAL technique. Sample statistical data were passed as input to this analysis services tool to find a feasible formulation method using CANAL technique of data mining. The result shows that the tablets containing OKG as binder - ncreases the rate of dissolution with moderate disintegration time. The dissolution profiles of tablets formulated with OKG were good at binder concentrations of 1 - 2 %w/w. Analysis proved OKG to be the most economical binder with respect to reduction of BFI values which is directly related to binders´ abilities to enrich capping and lamination in tablets. At 1.0%w/w concentration, OKG reduced the BFI of paracetamol tablets to an acceptable level (0.296), and it has proved to be more effective and economical. OKG is therefore recommended as an alternative to PVP, an expensive binder. This may be helpful in emerging world-shattering formulation and dosage forms which would enhance the drug soluble and dissolution rate in future with Cost-effectiveness.