Title :
Analysis of hydration and dehydration on xanthine related compounds during pharmaceutical granulation process using terahertz spectroscopy
Author :
Sakamoto, Takanori ; Sasaki, T. ; Kimura, Hiromitsu ; Hiyama, Yukio ; Katori, Noriko ; Okuda, Haruhisa
Author_Institution :
Div. of Drugs, Nat. Inst. of Health Sci., Tokyo, Japan
Abstract :
Hydration and dehydration processes during a pharmaceutical granulation process of xanthine related compounds were investigated using terahertz/far-infrared, mid-infrared and near-infrared electromagnetic waves. Certain kinds of xanthine related compounds and binders gave hydration and/or dehydration.
Keywords :
biochemistry; bioelectric phenomena; biomagnetism; dissociation; drugs; electromagnetic waves; infrared spectra; molecular biophysics; solvation; spectrochemical analysis; terahertz wave spectra; binders; dehydration; hydration; midinfrared electromagnetic waves; near-infrared electromagnetic waves; pharmaceutical granulation process; terahertz spectroscopy; terahertz-far-infrared electromagnetic waves; xanthine related compounds; Absorption; Atmospheric measurements; Compounds; Heating; Hydrogen; Pharmaceuticals; Temperature measurement;
Conference_Titel :
Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), 2013 38th International Conference on
Conference_Location :
Mainz
DOI :
10.1109/IRMMW-THz.2013.6665549
