Title :
Nucleosides analogs recognition by molecularly imprinted polymer- coated love wave sensor
Author :
Lebal, N. ; Hallil, H. ; Dejous, C. ; Plano, B. ; Krstulja, A. ; Delepee, R. ; Agrofoglio, L.A. ; Rebiere, D.
Author_Institution :
IMS Lab., Univ. Bordeaux, Talence, France
Abstract :
In this paper, we present a process for thin film MIP coating based on commercial nucleotides Adenosine Mono Phosphate (AMP). The compatibility of the MIP film with acoustic propagation and the sensor sensitivity for the rebinding of AMP has been verified. Thin and porous layers of AMP-based MIP layers were successfully deposited on the sensor surface. Detection tests of AMP have been performed in aqueous media. The sensor response was recorded in terms of frequency and total insertion losses after both steps: AMP extraction from MIP then AMP rebinding. The sensor showed high sensitivity to 25 ppm AMP concentration.
Keywords :
Love waves; biochemistry; biomedical ultrasonics; biosensors; molecular biophysics; polymer films; surface acoustic wave sensors; thin film sensors; AMP concentration; AMP extraction; AMP rebinding; AMP-based MIP layers; MIP film; acoustic propagation; aqueous media; coated love wave sensor; commercial nucleotide Adenosine Mono Phosphate; molecularly imprinted polymer; nucleoside analog recognition; porous layers; sensor sensitivity; sensor surface; thin film MIP coating; thin layers; total insertion losses; AMP detection; Love wave sensor; cancer biomarkers; thin film molecularly imprinted polymer;
Conference_Titel :
Microelectronics Technology and Devices (SBMicro), 2013 Symposium on
Conference_Location :
Curitiba
Print_ISBN :
978-1-4799-0516-4
DOI :
10.1109/SBMicro.2013.6676128
