Compact, low cost CMOS integrated SPR biosensor system

In this report, we propose a low cost, single chip, point of care CMOS integrated localized surface Plasmon resonance (LSPR) biosensor system. This system is composed of three unique functional layers in which two layers are integrated on to a single chip using conventional CMOS fabrication process to cut down the cost and improve the system sensitivity. Finite difference time domain (FDTD) simulations of nanohole array for before and after binding of antigen-antibody pairs gave a 10% change in the CMOS image sensor (CIS) response.