Telemetry controlled simultaneous microstimulation and recording device for studying cortical plasticity

This paper describes a telemetric interactive intracortical microstimulation (ICMS) and simultaneous recording device developed to deliver chronic microstimulation to the ipsilateral cortex and monitor evoked responses from the contralateral cortex. The embedded device was developed utilizing a Programmable System on a Chip (PSoC) microcontroller that can be remotely configured through Bluetooth. This device, with dimensions of 42 mm × 71 mm, can deliver monophasic, biphasic or pseudophasic stimulation pulses (peak current: ≤ 100 μA, duration: ≤ 10 ms, delay: ≤ 40 ms, repetition rate: 0.5 to 1 Hz) to a physiologically identified site in primary somatosensory cortex (SI) and record single and multiunit responses within 367 to 6470 Hz from a homotopic site in contralateral SI. This device was bench tested and validated in vivo in rat.