Design and Simulation of Proportional Biological Operational Mu-Circuit

Author

Dechang Xu ; Zhipeng Cai ; Ke Liu ; Xiangmiao Zeng ; Yujing Ouyang ; Cuihong Dai ; Aiju Hou ; Dayou Cheng ; Jianzhong Li

Author_Institution

Sch. of Food Sci. & Eng., Harbin Inst. of Technol., Harbin, China

Volume

14

Issue

2

fYear

2015

fDate

Mar-15

Firstpage

248

Lastpage

253

Abstract

It is challenging yet desirable to quantitatively control the expression of a target gene in practice. We design a device-Proportional Biological Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that will be possible to regulate input-output proportionally by manipulating the RBS of hrpR, hrpS, tetR and output gene and used in the sensing of environmental weak signals such as dioxins.

Keywords

biomolecular electronics; genetics; logic gates; molecular biophysics; operational amplifiers; toxicology; AND-OR gate; dioxins; environmental weak signal sensing; gene expression; hrpR; hrpS; input-output regulation; operational amplifier; output gene; proportional biological operational Mu-circuit design; proportional biological operational Mu-circuit simulation; tetR; Biological system modeling; Integrated circuit modeling; Logic gates; Mathematical model; Nanobioscience; Proteins; Simulation; Modeling; proportional regulation; simulation;

fLanguage

English

Journal_Title

NanoBioscience, IEEE Transactions on

Publisher

ieee

ISSN

1536-1241

Type

jour

DOI

10.1109/TNB.2015.2403871

Filename

7042316