Title :
Design and Simulation of Proportional Biological Operational Mu-Circuit
Author :
Dechang Xu ; Zhipeng Cai ; Ke Liu ; Xiangmiao Zeng ; Yujing Ouyang ; Cuihong Dai ; Aiju Hou ; Dayou Cheng ; Jianzhong Li
Author_Institution :
Sch. of Food Sci. & Eng., Harbin Inst. of Technol., Harbin, China
Abstract :
It is challenging yet desirable to quantitatively control the expression of a target gene in practice. We design a device-Proportional Biological Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that will be possible to regulate input-output proportionally by manipulating the RBS of hrpR, hrpS, tetR and output gene and used in the sensing of environmental weak signals such as dioxins.
Keywords :
biomolecular electronics; genetics; logic gates; molecular biophysics; operational amplifiers; toxicology; AND-OR gate; dioxins; environmental weak signal sensing; gene expression; hrpR; hrpS; input-output regulation; operational amplifier; output gene; proportional biological operational Mu-circuit design; proportional biological operational Mu-circuit simulation; tetR; Biological system modeling; Integrated circuit modeling; Logic gates; Mathematical model; Nanobioscience; Proteins; Simulation; Modeling; proportional regulation; simulation;
Journal_Title :
NanoBioscience, IEEE Transactions on
DOI :
10.1109/TNB.2015.2403871
