A 1–50 GHz dielectric spectroscopy biosensor with integrated receiver front-end in 65nm CMOS

Author

Jun-Chau Chien ; Anwar, Mohd ; Erh-Chia Yeh ; Lee, L.P. ; Niknejad, Ali M.

Author_Institution

Univ. of California, Berkeley, Berkeley, CA, USA

fYear

2013

fDate

2-7 June 2013

Firstpage

1

Lastpage

4

Abstract

In this paper, an on-chip transmission-line sensor with integrated receiver front-end implemented in 65nm CMOS facilitates the measurement of complex permittivity from 1 to 50 GHz for liquid samples. A robust extraction model allows accurate prediction of sample permittivity based on reference liquid calibration and eases the design of the hardware. Front-end circuits include a 60 GHz distributed amplifier with noise-cancellation active termination to improve the noise figure below 18 GHz. Correlated-double-sampling technique is used in the measurement setup to reject system phase drift. The sensor achieves 1% permittivity sensitivity at 20 GHz through liquid measurements with a minimum sensing volume of 0.09 nL. The prototype chip consumes a total power of 114 mW.

Keywords

CMOS integrated circuits; amplifiers; biosensors; calibration; interference suppression; permittivity; permittivity measurement; signal sampling; CMOS; complex permittivity; correlated double sampling technique; dielectric spectroscopy biosensor; distributed amplifier; frequency 1 GHz to 50 GHz; frequency 60 GHz; front end circuits; integrated receiver front end; liquid measurement setup; noise cancellation active termination; noise figure; on-chip transmission line sensor; permittivity sensitivity; power 114 mW; reference liquid calibration; robust extraction model; sensing volume; size 65 nm; system phase drift; CMOS integrated circuits; Frequency measurement; Liquids; Permittivity; Permittivity measurement; Sensors; Transmission line measurements; coplanar waveguide; correlated-double-sampling; distributed amplifier; microfluidics; noise-cancellation; permittivity measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Microwave Symposium Digest (IMS), 2013 IEEE MTT-S International

Conference_Location

Seattle, WA

ISSN

0149-645X

Print_ISBN

978-1-4673-6177-4

Type

conf

DOI

10.1109/MWSYM.2013.6697466

Filename

6697466