Modeling and simulation of electroporation system with measured bioimpedance: Determining parameters

The aims of this research is to determine electroporation parameters for a specific biological tissue application. Electroporation is a technique that facilitates the introduction of very small materials into biological cells by applying a high pulsed electric field. The success of electroporation is determined by parameters of the exposure and the properties of tissue. The biological tissue is modeled as a medium with conductivity and permittivity. Both properties are obtained from measurement of the impedance. The whole electroporation system forms an electromagnetic system which appeared as mathematical model of partial differential equation problems. A finite element method (FEM) is used as a tool to solve and simulate the problem. FEM gives graphical presentations showing the potential dan electric field distribution. A map of electroporation that based on electric field exposure is then analyzed to obtain an electroporation area. The results are electroporation parameters in term of electrodes potential different and distance, duration, number, and interval of the pulses. It can be done by choosing the respective parameters that produce certain electroporation area. Some sets of parameters that produce a wide range of electroporation area are also presented.