Functionalized superparamagnetic nanoparticles as versatile carriers for targeted antioxidant enzyme therapy

Author

Balan, Viorel ; Butnaru, Maria ; Bredetean, Ovidiu ; Verestiuc, Liliana ; Profire, Lenuta ; Lupascu, Geanina ; Chiriac, Aurica ; Nita, Loredana ; Neamtu, Iordana

Author_Institution

Dept. of Biomed. Sci., Grigore T.Popa Univ. of Med. & Pharmacy, Iasi, Romania

fYear

2013

fDate

21-23 Nov. 2013

Firstpage

1

Lastpage

4

Abstract

Functionalized superparamagnetic nanoparticles based on poly (succinimide)- b -poly(ethylene glycol) and magnetite have been obtained by immobilization of superoxide dismutase via activation with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride (EDAC). Dynamic light scattering measurements showed that hydrodynamic mean diameters of the functionalized particles were about 700 nm. These particles exhibit a superparamagnetic behaviour and high magnetic saturation, good cell biocompatibility and enzymatic activity, characteristics that recommend them in application as versatile carriers for targeted antioxidant enzyme therapy.

Keywords

cellular biophysics; enzymes; iron compounds; magnetic particles; nanocomposites; nanomagnetics; nanomedicine; nanoparticles; organic-inorganic hybrid materials; polymers; superparamagnetism; 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride; EDAC activation; Fe₃O₄; antioxidant enzyme carriers; cell biocompatibility; dynamic light scattering measurements; enzymatic activity; functionalized superparamagnetic nanoparticles; hydrodynamic mean diameter; magnetic saturation; magnetite; poly(succinimide)-b-poly(ethylene glycol); superoxide dismutase immobilization; targeted antioxidant enzyme therapy; Cells (biology); Chemistry; Magnetic resonance imaging; Nanobioscience; Nanoparticles; Polymers; antioxidant enzyme; biomedical applications; functionalization; superparamagnetic nanoparticles;

fLanguage

English

Publisher

ieee

Conference_Titel

E-Health and Bioengineering Conference (EHB), 2013

Conference_Location

Iasi

Print_ISBN

978-1-4799-2372-4

Type

conf

DOI

10.1109/EHB.2013.6707334

Filename

6707334