Title :
Functionalized superparamagnetic nanoparticles as versatile carriers for targeted antioxidant enzyme therapy
Author :
Balan, Viorel ; Butnaru, Maria ; Bredetean, Ovidiu ; Verestiuc, Liliana ; Profire, Lenuta ; Lupascu, Geanina ; Chiriac, Aurica ; Nita, Loredana ; Neamtu, Iordana
Author_Institution :
Dept. of Biomed. Sci., Grigore T.Popa Univ. of Med. & Pharmacy, Iasi, Romania
Abstract :
Functionalized superparamagnetic nanoparticles based on poly (succinimide)- b -poly(ethylene glycol) and magnetite have been obtained by immobilization of superoxide dismutase via activation with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride (EDAC). Dynamic light scattering measurements showed that hydrodynamic mean diameters of the functionalized particles were about 700 nm. These particles exhibit a superparamagnetic behaviour and high magnetic saturation, good cell biocompatibility and enzymatic activity, characteristics that recommend them in application as versatile carriers for targeted antioxidant enzyme therapy.
Keywords :
cellular biophysics; enzymes; iron compounds; magnetic particles; nanocomposites; nanomagnetics; nanomedicine; nanoparticles; organic-inorganic hybrid materials; polymers; superparamagnetism; 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride; EDAC activation; Fe3O4; antioxidant enzyme carriers; cell biocompatibility; dynamic light scattering measurements; enzymatic activity; functionalized superparamagnetic nanoparticles; hydrodynamic mean diameter; magnetic saturation; magnetite; poly(succinimide)-b-poly(ethylene glycol); superoxide dismutase immobilization; targeted antioxidant enzyme therapy; Cells (biology); Chemistry; Magnetic resonance imaging; Nanobioscience; Nanoparticles; Polymers; antioxidant enzyme; biomedical applications; functionalization; superparamagnetic nanoparticles;
Conference_Titel :
E-Health and Bioengineering Conference (EHB), 2013
Conference_Location :
Iasi
Print_ISBN :
978-1-4799-2372-4
DOI :
10.1109/EHB.2013.6707334
