Approximate entropy can localize rotors, but not ectopic foci during chronic atrial fibrillation: A simulation study

Author

Orozco-Duque, A. ; Ugarte, J.P. ; Tobon, C. ; Saiz, J. ; Bustamante, J.

Author_Institution

Centro de Bioingenieria, Univ. Pontificia Bolivariana, Medellin, Colombia

fYear

2013

fDate

22-25 Sept. 2013

Firstpage

903

Lastpage

906

Abstract

Rotors and ectopic foci are targets for ablation to revert atrial fibrillation (AF). Spectral analysis is not accurate for rotor localization during chronic AF. Studies suggest that complex fractionated atrial electrograms (CFAE) are generated by rotor tips. The aim of this work is to locate rotor tips applying approximate entropy (ApEn), which is a non-linear dynamic measure. For this, a chronic AF episode was simulated in a 3D model of human atria. Electrograms were simulated in the atrial surface and ApEn was calculated. Our results show that high ApEn values matched with rotor tips. This findings suggest that targeting ApEn areas may potentially be effective in identifying rotor tips for ablation in chronic AF.

Keywords

electrocardiography; entropy; medical disorders; surgery; 3D human atria model; ApEn; CFAE; ablation; approximate entropy; chronic AF; chronic atrial fibrillation; complex fractionated atrial electrograms; ectopic foci; electrograms; rotor localization; Atrial fibrillation; Electric potential; Entropy; Mathematical model; Rotors; Solid modeling; Three-dimensional displays;

fLanguage

English

Publisher

ieee

Conference_Titel

Computing in Cardiology Conference (CinC), 2013

Conference_Location

Zaragoza

ISSN

2325-8861

Print_ISBN

978-1-4799-0884-4

Type

conf

Filename

6713524