Derivation and Numerical Verification of a Compact Analytical Model for the AC Admittance Response of Nanoelectrodes, Suitable for the Analysis and Optimization of Impedance Biosensors

Author

Pittino, Federico ; Scarbolo, Paolo ; Widdershoven, Frans ; Selmi, Luca

Author_Institution

Univ. degli Studi di Udine, Udine, Italy

Volume

14

Issue

4

fYear

2015

fDate

Jul-15

Firstpage

709

Lastpage

716

Abstract

This paper presents a compact analytical model for the AC response of nanoelectrode-based impedimetric biosensors to dielectric nanoparticles suspended in the electrolyte. The model highlights the functional dependence of the impedance change on the nanoparticle and the system geometrical and physical parameters. The model is carefully verified by means of 2-D simulations carried out with an ad hoc numerical solver of the Poisson-Nernst-Planck (Poisson-Drift-Diffusion) equations. The results can be useful to determine optimum detection conditions for impedimetric nanobiosensors, and to interpret experimental results.

Keywords

Poisson equation; biosensors; diffusion; electric admittance; electrolytes; nanobiotechnology; nanoparticles; nanosensors; numerical analysis; 2D simulations; Poisson-Nernst-Planck equation; Poisson-drift-diffusion equation; ad hoc numerical solver; compact analytical model; dielectric nanoparticles; electrolyte; geometrical parameter; impedance change; impedimetric nanobiosensors; nanoelectrode AC admittance response; optimum detection conditions; physical parameter; Admittance; Analytical models; Biological system modeling; Biosensors; Electrodes; Mathematical model; Numerical models; AC nanoelectrode biosensor; compact analytical model; dielectric nanoparticles; numerical simulation; optimum detection conditions;

fLanguage

English

Journal_Title

Nanotechnology, IEEE Transactions on

Publisher

ieee

ISSN

1536-125X

Type

jour

DOI

10.1109/TNANO.2015.2434106

Filename

7109161