Differential coexpression analysis in gene modules level and its application to type 2 diabetes

More and more studies have shown many complex diseases are contributed jointly by alterations of numerous genes. In this paper, we propose a gene differential coexpression analysis algorithm in the level of gene sets and apply the algorithm to a publicly available type 2 diabetes (T2D) expression dataset. The experimental results on simulated data show that the new approach performed well. Moreover, we apply the new approach to clinical data, many additional discoveries can be found through our method.