• DocumentCode
    685473
  • Title

    Multifractal Analysis of Disease-Related Gene Networks

  • Author

    Danling Wang ; Yanfei Wang

  • Author_Institution
    Sch. of Math. & Phys., Univ. of Sci. & Technol. Beijing, Beijing, China
  • Volume
    1
  • fYear
    2013
  • fDate
    28-29 Oct. 2013
  • Firstpage
    338
  • Lastpage
    341
  • Abstract
    In this paper, we introduce a new box-covering algorithm to compute the generalized fractal dimensions of complex networks. We apply our method on networks built on disease-related gene micro array data. For each micro array data, we compare the difference of multifractal behaviour between gene networks that reconstructed from patients and normal micorarrays. The result suggests that multifractality exists in all the gene networks we generated and the differences in the shape of the Dq curves are obvious for all micro array data sets. Thus multifractal analysis could provide a potentially useful tool for gene clustering and identification between healthy people and patients.
  • Keywords
    bioinformatics; complex networks; diseases; fractals; genetics; pattern clustering; Dq curves; box-covering algorithm; complex networks; disease-related gene microarray data sets; disease-related gene networks; gene clustering; generalized fractal dimensions; healthy people identification; multifractal behaviour analysis; patient identification; Bioinformatics; Cancer; Complex networks; Diabetes; Diseases; Educational institutions; Fractals; Multifractal; box-covering algrithm; complex networksg; disease-related genes;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Computational Intelligence and Design (ISCID), 2013 Sixth International Symposium on
  • Conference_Location
    Hangzhou
  • Type

    conf

  • DOI
    10.1109/ISCID.2013.91
  • Filename
    6805004