• DocumentCode
    688561
  • Title

    Label-free kinetic screening of proteins and virus binding in A 51,200 small-molecule library with a high-throughput ellipsometric scanning microscope

  • Author

    Malovichko, G. ; Landry, James P. ; Proudian, Andrew P. ; Xiangdong Zhu

  • Author_Institution
    Dept. of Phys.., Univ. of California at Davis, Davis, CA, USA
  • fYear
    2013
  • fDate
    9-14 June 2013
  • Firstpage
    1
  • Lastpage
    2
  • Abstract
    Using a label-free high-throughput optical scanning microscope we detected endpoints and binding kinetics of RNPC1a, Pyl(1&2) proteins and influenza virus A/PR/8/34 with a library of 51,200 small-molecule compounds from the NCI Developmental Therapeutics Program.
  • Keywords
    ellipsometry; microorganisms; molecular biophysics; optical microscopy; proteins; RNPC1a binding kinetics; high-throughput ellipsometric scanning microscope; influenza virus binding kinetics; label-free kinetic screening; protein binding kinetics; small-molecule compounds; Biomedical optical imaging; Compounds; Kinetic theory; Libraries; Probes; Proteins; Real-time systems;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Lasers and Electro-Optics (CLEO), 2013 Conference on
  • Conference_Location
    San Jose, CA
  • Type

    conf

  • Filename
    6832935
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=688561