Modeling the Superovulation Stage in In Vitro Fertilization

In vitro fertilization (IVF) is the most common technique in assisted reproductive technology and in most cases the last resort for infertility treatment. It has four basic stages: superovulation, egg retrieval, insemination/fertilization, and embryo transfer. Superovulation is a drug-induced method to enable multiple ovulation per menstrual cycle. The success of IVF majorly depends upon successful superovulation, defined by the number and similar quality of eggs retrieved in a cycle. Modeling the superovulation stage can help in predicting the outcomes of IVF before the cycle is complete. In this paper, we developed a model for superovulation stage. The model is adapted from the theory of batch crystallization. The aim of crystallization is to get maximum crystals of similar size and purity, while superovulation aims at eggs of similar quality and size. The rate of crystallization and superovulation are both dependent on the process conditions and varies with time. The kinetics of follicle growth is modeled as a function of injected hormones and the follicle properties are represented in terms of the moments. The results from the model prediction were verified with the known data from Jijamata Hospital, Nanded, India. The predictions were found to be in agreement with the actual observations.