An adaptive approach to Target Controlled Infusion

This paper proposes an adaptive approach to improve the performance of Target Controlled Infusion (TCI) based strategies. The method determines an adequate drug dose profile that drives the drug effect on the individual patient to a desired target in a prespecified period of time. It combines an optimal variance constrained drug dose design with a hybrid identification of the individual patient dynamics. Simulation results based on a bank of one hundred neuromuscular blockade patient models are presented to demonstrate the feasibility of the proposed method.