Optimal parametric sensitivity control for a FED batch reactor

The paper presents a method to derive an optimal parametric sensitivity controller for optimal estimation of a set of parameters in an experiment. The method is demonstrated for a fed batch bio-reactor case study for optimal estimation of the saturation constant K_s and, albeit intuitively, the parameter combination μ_maxX/Y where μ_max is the maximum growth rate [g/min], Y is the yield coefficient [g/g], and X is the (constant) biomass [g].