Effect of immobilisation of magnetic nanoparticles on MPS-signal

Author

Eberbeck, D. ; Khandhar, A.P. ; Krishnan, K.M. ; Trahms, L.

Author_Institution

Phys.-Tech. Bundesanstalt, Berlin, Germany

fYear

2015

fDate

26-28 March 2015

Firstpage

1

Lastpage

1

Abstract

How immobilization of MPI tracers changes the MPS-signal? To address this question we immobilized a sample with single core and a sample with multicore magnetic nanoparticles (MNP) in different matrices. In order to catch a possible effect of dipolar interaction between MNP, here we focus on large, high performing MNP which are preferable for MPI. The knowledge, how the immobilization affects MPS amplitude as well as MPI performance is important for the measurement of quantitative distribution of tracers (quantitative imaging) and for proper quantification of them by MPS, e.g. in cells and in MPS-based binding assays.

Keywords

biomagnetism; biomedical imaging; cellular biophysics; gelatin; magnetic particles; molecular biophysics; nanomagnetics; nanomedicine; nanoparticles; MPI tracers; MPS signal; MPS-based binding assays; cells; dipolar interaction; immobilization effect; magnetic nanoparticles; multicore magnetic nanoparticles; quantitative distribution; quantitative imaging; single core; Magnetic cores; Magnetic domains; Magnetic resonance imaging; Magnetic separation; Multicore processing; Perpendicular magnetic anisotropy;

fLanguage

English

Publisher

ieee

Conference_Titel

Magnetic Particle Imaging (IWMPI), 2015 5th International Workshop on

Conference_Location

Istanbul

Print_ISBN

978-1-4799-7269-2

Type

conf

DOI

10.1109/IWMPI.2015.7107003

Filename

7107003